Product ID:CYTOXAN FOR INJECTION (200 MG)
MSDS Date:03/01/1990
FSC:6505
NIIN:01-316-0265
MSDS Number: BKYYQ

Emergency Phone: (812) 429-5678 OR (812) 429-5000

Info Phone: (812) 429-5678 OR (812) 429-5000

Cage: DO726

Telephone: 812-429-5140

Cage: DO726

CYCLOPHOSPHAMIDE HYDRATE

CAS: 6055-19-2

RTECS: RP6157750

Fraction By Weight: 70%

LD50 LC50 Mixture:ORAL LD50 (RAT):134 MG/KG.
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:EYES: CONJUNCTIVITIS. SKIN: ABSORPTION
& RASH. INGESTION: CYTOTOXIC AGENT, BONE MARROW SUPPRESSION,
GENITO-URINARY, LUNG, CARDIAC & GASTROINTESTINAL TOXICITY.
Explanation of Carcinogenicity:CYCLOPHOSPHAMIDE MONOHYDRATE IS A HUMAN
CARCINOGEN.
Effects of Overexposure:EYES: CONJUNCTIVITIS. SKIN: ABSORPTION & RASH.
INGESTION: CYTOTOXIC AGENT, BONE MARROW SUPPRESSION,
GENITO-URINARY, LUNG, CARDIAC & GASTROINTESTINAL TOXICITY.

First Aid:EYES: FLUSH W/PLENTY OF WATER FOR 15 MIN. SKIN: WASH W/SOAP &
WATER. INGESTION/INHALATION: OBTAIN MEDICAL ATTENTION IN ALL CASES.

Extinguishing Media:WATER, CO2 & DRY CHEMICAL
Fire Fighting Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS & FULL
PROTECTIVE CLOTHING.

Spill Release Procedures:WIPE LIQUIDS W/ABSORBENT GAUZE PADS. WIPE
SOLIDS W/WET ABSORBENT GAUZE. CLEAN USING DETERGENT & WATER. COVER
LIQUID W/ABSORBENT SHEETS, SPILL CONTROL PADS OR PILLOWS. COVER
POWDER W/DAMP CLOTH OR TOWE LS. DOUBLE GLOVING IS RECOMMENDED.

Handling and Storage Precautions:DON'T STORE FOOD NEAR PREPARATION
AREA. STORE AT OR BELOW 77F. AVOID EATING, DRINKING, SMOKING,
CHEWING GUM OR APPLYING COSMETICS IN PREPARATION AREA.
Other Precautions:AVOID CUTS FROM GLASS IF VIALS BREAK DURING SPILL.
GLOVES SHOULD BE CHANGED REGULARLY & REMOVE AFTER OVER
CONTAMINATION.

Respiratory Protection:USE NIOSH APPROVED DUST RESPIRATOR W/HIGH
EFFICIENCY DUST FILTER OR POWERED AIR-PURIFYING RESPIRATOR IF
BIOLOGICAL SAFETY CABINET IS NOT AVAILABLE OR >TLV.
Ventilation:BIOLOGICAL SAFETY CABINET FOR PREPARATION OR AS DETERMINED
BY INDUSTRIAL HYGIENIST.
Protective Gloves:SURGICAL LATEX
Eye Protection:SAFETY GLASSES W/PLASTIC FACE SHIELD
Other Protective Equipment:SPLASH GOGGLES, DISPOSABLE GOWN OF LOW
PERMEABILITY FABRIC W/CLOSED FRONT, LONG SLEEVES & ELASTIC CUFFS
Work Hygienic Practices:WASH THOROUGHLY BEFORE EATING OR SMOKING.
Supplemental Safety and Health
A PRE-PLACEMENT PHYSICAL EXAMINATION & HISTORY FOR EMPLOYEES
W/POTENTIAL EXPOSURE TO CYTOXAN IS RECOMMENDED. STAFF MEMBERS WHO
ARE PREGNANT, ARE BREAST-FEEDING, OR WHO ARE CONCERNED W/OTHER
REPRODUCTI VE ISSUES SHOULD BE ENCOURGED TO CONSULT W/OCCUPATIONAL
HEALTH PHYSICIAN MONITORING WORKER'S HEALTH.

Melt/Freeze Pt:M.P/F.P Text:105.8-113F
Solubility in Water:40 MG/ML
Appearance and Odor:WHITE POWDER

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:HEAT & TEMPERATURES >77F
Hazardous Decomposition Products:TOXIC FUMES OF CHLORIDE, NITROGEN
OXIDES & PHOSPHOROUS OXIDES & HEAT
Conditions to Avoid Polymerization:MAY OCCUR AT TEMPERATURES >120F.

Waste Disposal Methods:U058 (HAZARDOUS WASTE). LAND DISPOSAL IS
PROHIBITED. INCINERATE ACCORDING TO FEDERAL, STATE & LOCAL
REGULATIONS. FEDERAL LAW PROHIBITS DISPENSING W/O PRESCRIPTION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.